Antimicrobial resistance (AMR) has emerged as a salient threat to human health. Among the contributors to the sustained threat of AMR is the utility and management of antibiotics in food-production systems. There is urgent need for an integrated strategy involving human health, agriculture, environment, public education and policy to identify and map practices, stewardship, knowledge, and related gaps in the LAC region. A key outcome required is to analyze risks to human health and economic sustainability and develop informed policies for surveillance, treatment and prevention.